New works relative to explore the PD-L1-targeted effects of mechanistically diverse metabolism-targeting drugs have been supported by the UMH Supercomputing Cluster (Castleblack). It is a new paper published in which is collected computing work done in the cluster of the UMH.

Using biochemical assays, computer-aided docking/molecular dynamics simulations, and fluorescence microscopy, the authors of this research have found that RSV can operate as a direct inhibitor of glyco-PD-L1-processing enzymes (α-glucosidase/α-mannosidase) that modulate N-linked glycan decoration of PD-L1, thereby promoting the endoplasmic reticulum retention of a mannose-rich, abnormally glycosylated form of PD-L1.

The paper has been titled as “Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity”, and has been published at AGING (DOI https://doi.org/10.18632/aging.102646)

Reference: Verdura S., Cuyas E., Cortada E., Brunet J., Lopez-Bonet E., Martin-Castillo B., Bosch-Barrera J., Encinar J.A. and Menendez J.A. Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity. 2020. AGING, Vol. 12. doi: https://doi.org/10.18632/aging.102646